临床外科杂志2024,Vol.32Issue(3) :328-331.DOI:10.3969/j.issn.1005-6483.2024.03.030

免疫检查点抑制剂治疗晚期肝细胞癌的研究进展

Current progress of immune checkpoint inhibitors in the treatment of advanced hepatocellular carcinoma

周一 梁宾勇 肖震宇
临床外科杂志2024,Vol.32Issue(3) :328-331.DOI:10.3969/j.issn.1005-6483.2024.03.030

免疫检查点抑制剂治疗晚期肝细胞癌的研究进展

Current progress of immune checkpoint inhibitors in the treatment of advanced hepatocellular carcinoma

周一 1梁宾勇 1肖震宇1
扫码查看

作者信息

  • 1. 430030 武汉,华中科技大学同济医学院附属同济医院肝脏外科
  • 折叠

摘要

肝细胞癌(hepatocellular carcinoma,HCC)是我国常见的恶性肿瘤,起病隐匿,病人就诊时多为中晚期,失去手术机会,预后极差.近年来,以免疫检查点抑制剂(immune checkpoint in-hibitors,ICIs)为代表的免疫治疗在晚期HCC治疗中日益普及,但仍有许多病人治疗效果不理想.ICIs与其他治疗的联合方案已成为治疗晚期HCC最有潜力的策略.本文对ICIs单药或联合其他治疗在晚期HCC治疗中的最新研究进展进行综述.

Abstract

Hepatocellular carcinoma(HCC),frequently diagnosed at advanced stages in China due to insidious onset,faces a dismal prognosis with limited surgical feasibility.The advent of immunotherapy,particularly immune checkpoint inhibitors(ICIs),introduces novel therapeutic prospects,albeit with variable efficacies.The combination of ICIs with various therapeutic strategies is increasingly recognized as a critical approach in the management of advanced HCC.This article reviews recent advances in ICIs for advanced hepatocellular carcinoma and discusses the future prospects of immunotherapy.

关键词

晚期肝细胞癌/免疫检查点抑制剂/联合治疗

Key words

advanced hepatocellular carcinoma/immune checkpoint inhibitors/combination therapy

引用本文复制引用

出版年

2024
临床外科杂志
中华医学会湖北分会

临床外科杂志

CSTPCD
影响因子:0.716
ISSN:1005-6483
参考文献量31
段落导航相关论文