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胆汁反流发病机制与诊断及治疗研究进展

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胆汁反流是由于胆汁逆行运动到胃及其以上部位,长期的胆汁反流除了引起胆汁反流性胃炎外,还可导致肠化、Barrett食管,甚至是胃癌、食管癌、咽喉癌的高危因素.长期频繁的胆汁反流应视为病理性胆汁反流,胆汁反流分为原发性反流和继发性反流.临床上胆汁反流常见的症状包括腹胀、口苦、上腹痛、恶心呕吐等.原发性胆汁反流无胃手术即可发生,而继发性胆汁反流通常在胃肠手术后发生.本文对胆汁反流发病机制与诊断和治疗进展进行综述.
Advances in pathogenesis,diagnosis and treatment of bile reflux
Bile reflux is a common physiological phenomenon in the body,which is caused by the retrograde movement of bile into the stomach and above.Long-term bile reflux causes bile reflux gastritis.It can also lead to intestinal metaplasia,Barrett's esophagus,and even gastric cancer,esophageal cancer,pharyngeal cancer risk factors.Therefore,long-term frequent bile reflux should be regarded as pathological bile reflux.bile reflux is divided into primary bile reflux and secondary bile reflux.The common clinical symptoms of bile reflux include abdominal distension,bitter mouth,upper abdominal pain,nausea and vomiting.Primary bile reflux can occur without transgastric surgery,whereas secondary bile reflux often occurs after gastrointestinal surgery.This article reviews the pathogenesis,diagnosis and corresponding treatment progress of bile reflux,so as to provide reference for further research on bile reflux.

bile refluxtreatmentpathogenesisbile acidsintestinalizationlaryngopharyngeal reflux

董泓毅、刘殿刚

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100053 北京,首都医科大学宣武医院普通外科

胆汁反流 治疗 发病机制 胆汁酸 肠化 咽喉反流

北京市自然科学基金-海淀原始创新联合基金

L182048

2024

临床外科杂志
中华医学会湖北分会

临床外科杂志

CSTPCD
影响因子:0.716
ISSN:1005-6483
年,卷(期):2024.32(5)
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