Research Progress on Predictive Factors and Related Predictive Models for Anastomotic Leakage After Esophageal Cancer Surgery
Anastomotic leakage is one of the most severe complications following esophagectomy.Research on predictive factors is crucial for its prevention.Blood markers such as C-reactive protein,white blood cell count,procalcitonin,and albumin levels are widely used due to their accessibility,but they have limitations in distinguishing anastomotic leakage from other postoperative infections.The assessment of blood supply to the anastomotic site,including factors like vessel length and diameter,is also readily obtainable and valuable in predictive models,though there is limited research in this area.The use of indocyanine green offers a more direct evaluation of blood supply,but its application is not widespread,and data acquisition is challenging.Preoperative comorbidities such as diabetes have been shown to delay wound healing and increase the risk of leakage;thus,it is recommended to include these factors in comprehensive studies.Although surgical techniques and the location of the anastomosis have been extensively studied,further exploration of these details is necessary.Researchers should integrate these factors to develop multifactorial predictive models,enabling the identification of high-risk patients preoperatively and the implementation of effective preventive measures to reduce the incidence of anastomotic leakage.
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