Association of cholinesterase levels with sarcopenia and postoperative infection risk in patients with gastric cancer after surgery
[Abstact]Objective To investigate the correlation between cholinesterase(ChE)level and the risk of sarcopenia and postoperative infection in patients with gastric cancer.Methods 125 patients with gastric cancer in our hospital from June 2022 to July 2023 were selected as the study objects,all of whom received radical gastrectomy.Serum ChE levels were detected 1 day before surgery and 5 days after surgery,relevant infectious agents were detected on the 5th day after surgery.The incidence of postoperative sarcopenia and postoperative infection were recorded in the two groups according to the dichotomous ChE level.Pearson correlation was used to analyze the correlation between serum ChE level and sarcopenia and postoperative infection.Results After operation,the serum ChE level of 125 patients with gastric cancer was(263.86±51.57)U/L.According to the dichotomous number of serum ChE level,62 cases were divided into high level group(ChE ≥ 267.03 U/L)and 63 cases were divided into low level group(ChE＜267.03 U/L).The incidence of sarcopenia in high level group was lower than that in low level group,and the walking speed,grip strength and muscle mass levels were higher than those in low level group(P＜0.05).The incidence of sarcopenia in high level group was lower than that in low level group,and the levels of C-reactive protein(CRP),interleukin(IL-6)and procalcitonin(PCT)were lower than those in low level group(P＜0.05).pearson correlation analysis showed that ChE level was positively correlated with walking speed,grip strength and muscle mass(r=0.479,P＜0.05;r=0.606,P＜0.05;r=0.513,P＜0.05),CRP,IL-6 and PCT were negatively correlated with postoperative infection(r=-0.545,P＜0.05;r=-0.836,P＜0.05;r=-0.468,P＜0.05).Conclusion Serum ChE is associated with the risk of postoperative sarcopenia and postoperative infection for gastric cancer.
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