血清乳脂球表皮生长因子8、富亮氨酸α-2糖蛋白-1对重症胰腺炎病人急性肾损伤的预测价值
Predictive value of serum milk fat globule-EGF factor 8 protein and leucine rich alpha-2 glycoprotein 1 levels for acute kidney injury in patients with severe pancreatitis
汝丽娟 1高现同 1姚倩倩1
作者信息
- 1. 266300 青岛市胶州中心医院重症医学科
- 折叠
摘要
目的 探究血清乳脂球表皮生长因子8(MFG-E8)、富亮氨酸α-2糖蛋白-1(LRG1)对重症胰腺炎病人急性肾损伤(AKI)的预测价值.方法 2020年1月～2023年8月收治的重症胰腺炎病人100例.根据48小时内是否发生AKI分为两组,AKI组43例,非AKI组57例.采用酶联免疫吸附法(ELISA)测定入院时各组血清MFG-E8、LRG1水平.采用Spearman相关性分析血清MFG-E8、LRG1表达水平与急性生理和慢性健康状况评分Ⅱ(APACHE Ⅱ)的相关性.采用多因素Logistic回归分析影响重症胰腺炎病人AKI的因素.采用受试者工作特征(ROC)曲线分析血清MFG-E8、LRG1对重症胰腺炎病人AKI的预测价值.结果 与非AKI组相比,AKI组LRG1的表达水平上调(P＜0.05),MFG-E8的表达水平下调,两组比较差异有统计学意义(P＜0.05).重症胰腺炎病人血清MFG-E8水平和APACHE Ⅱ评分存在负相关性(r=-0.444,P＜0.05),血清LRG1水平和APACHE Ⅱ评分存在正相关性(r=0.655,P＜0.05).多因素Logistic回归分析发现,血清MFG-E8为重症胰腺炎病人AKI的保护因素(P＜0.05).LRG1、血清肌酐、尿酸均为重症胰腺炎病人AKI的危险因素(P＜0.05).血清MFG-E8和LRG1两者联合预测重症胰腺炎病人AKI优于MFG-E8、LRG1 各自单独预测(Z 二者联合-MFG-E8=2.952,P=0.003;Z 二者联合-LRG1=2.385,P=0.017).结论 重症胰腺炎AKI病人血清MFG-E8表达水平显著下调,LRG1表达水平显著上调,两者联合可用于重症胰腺炎病人AKI的预测.
Abstract
Objective To explore the predictive value of serum milk fat globule-EGF factor 8 protein(MFG-E8)and leucine rich alpha-2 glycoprotein 1(LRG1)for acute kidney injury(AKI)in patients with severe pancreatitis.Methods A study was conducted on 100 patients with severe pancreatitis admitted to our hospital from January 2020 to August 2023.They were grouped into AKI group(43 cases)and non AKI group(57 cases)based on whether AKI occurred within 48 hours.Enzyme linked immunosorbent assay(ELISA)was applied to determine the levels of serum MFG-E8 and LRG1 in each group.Spearman correlation was applied to analyze the correlation between serum MFG-E8,LRG1 expression levels and Acute Physiological And Chronic Health Evaluation Ⅱ(APACHE Ⅱ).Logistic regression was applied to analyze the factors affecting AKI in patients with severe pancreatitis.Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum MFG-E8 and LRG1 for AKI in patients with severe pancreatitis.Results Compared with the non AKI group,the expression level of LRG1 in the AKI group was obviously increased(P＜0.05),while the expression level of MFG-E8 was significantly reduced(P＜0.05).There was a negative correlation between serum MFG-E8 level and APACHE Ⅱ score in severe pancreatic patients(r=-0.444,P＜0.05),while there was a positive correlation between serum LRG1 level and APACHE Ⅱ score(r=0.655,P＜0.05).The results of multivariate Logistic regression analysis showed that serum MFG-E8 was a protective factor for AKI in patients with severe pancreatitis(P＜0.05).LRG1,serum creatinine,and uric acid were all risk factors for AKI in patients with severe pancreatitis(P＜0.05).The combination of serum MFG-E8 and LRG1 in predicting AKI in patients with severe pancreatitis was superior to MFG-E8 and LRG1 alone in predicting AKI(Zcombination-MFG-E8=2.952,P=0.003;Zcombination-LRG1=2.385,P=0.017).Conclusion The serum MFG-E8 expression level is significantly reduced and LRG1 expression level is significantly increased in severe pancreatitis patients with AKI.The combination of the two can be used for predicting AKI in severe pancreatitis patients.
关键词
MFG-E8/LRG1/重症胰腺炎/急性肾损伤/预测Key words
milk fat globule-EGF factor 8 protein/leucine rich alpha-2 glycoprotein 1/severe pancreatitis/acute kidney injury/prediction引用本文复制引用
出版年
2024
NETL
NSTL
万方数据