Characteristics of intestinal flora in children with short bowel syndrome and modulation effect of probiotics
Children short bowel syndrome(SBS)is a malabsorption with acquired reduction in length of the small intestine or congenital bowel anomalies which cannot meet the needs of normal growth and development,and requires parenteral nutrition to support longer than 42 days.Due to the changes of intestinal structure and function,long-term intravenous nutrition,and antibiotic use,the intestinal flora of children with SBS is often disordered.Maintaining the diversity and stability of intestinal flora in children with SBS plays an important role in protecting the intestinal mucosal barrier,enhancing intestinal adaptation,withdrawing PN early,and reducing complications such as intestinal failure-related liver damage.Probiotics play an important role in maintaining the stability of intestinal flora,regulating metabolism and immunity.However,the role of probiotics in SBS is still controversial.This article summarizes the characteristics of intestinal flora in children with SBS and its effects on the body,and the role of probiotics in maintaining the homeostasis of intestinal flora in children with SBS,hoping to provide reference for the clinical treatment of children with SBS.
Short bowel syndromeintestinal flora disorderprobioticintestinal adapta-tion
NETL
NSTL
万方数据
