儿童短肠综合征肠道菌群特点及益生菌的调节作用
Characteristics of intestinal flora in children with short bowel syndrome and modulation effect of probiotics
桂琳玲 1唐维兵2
作者信息
- 1. 430016 武汉,华中科技大学同济医学院附属武汉儿童医院新生儿外科;南京医科大学附属儿童医院新生儿外科
- 2. 南京医科大学附属儿童医院新生儿外科
- 折叠
摘要
儿童短肠综合征(short bowel syndrome,SBS)是指小肠被大部分切除、旷置或先天性短肠等原因,导致小肠吸收能力受限,无法满足患儿正常生长发育的需求,需要肠外营养(parenter-al nutrition,PN)支持42天以上的症候群.由于肠道结构及功能的改变,以及长期静脉营养、抗生素的使用等因素,导致SBS患儿肠道菌群紊乱.维持SBS患儿肠道菌群多样性及稳定性,在保护肠黏膜屏障、增强肠适应、尽早脱离PN及减少肠衰竭相关性肝损害等并发症中具有重要意义.益生菌对维持肠道菌群稳定,调节代谢、免疫等均发挥重要作用,然而在SBS中的应用仍存在争议.本文总结儿童SBS肠道菌群特点及对机体的影响,益生菌在维持SBS肠道菌群稳态中的作用.
Abstract
Children short bowel syndrome(SBS)is a malabsorption with acquired reduction in length of the small intestine or congenital bowel anomalies which cannot meet the needs of normal growth and development,and requires parenteral nutrition to support longer than 42 days.Due to the changes of intestinal structure and function,long-term intravenous nutrition,and antibiotic use,the intestinal flora of children with SBS is often disordered.Maintaining the diversity and stability of intestinal flora in children with SBS plays an important role in protecting the intestinal mucosal barrier,enhancing intestinal adaptation,withdrawing PN early,and reducing complications such as intestinal failure-related liver damage.Probiotics play an important role in maintaining the stability of intestinal flora,regulating metabolism and immunity.However,the role of probiotics in SBS is still controversial.This article summarizes the characteristics of intestinal flora in children with SBS and its effects on the body,and the role of probiotics in maintaining the homeostasis of intestinal flora in children with SBS,hoping to provide reference for the clinical treatment of children with SBS.
关键词
短肠综合征/肠道菌群紊乱/益生菌/肠适应Key words
Short bowel syndrome/intestinal flora disorder/probiotic/intestinal adapta-tion引用本文复制引用
出版年
2024
NETL
NSTL
万方数据