Predictive value of 24-hour dynamic electrocardiogram parameters combined with serum brain natriuretic peptide and C-reactive protein for malignant ventricular arrhythmia after PCI in patients with acute myocardial infarction
Objective To investigate the predictive value of 24-hour dynamic electrocardiogram parameters combine with serum brain natriuretic peptide(BNP)and C-reactive protein(CRP)for malignant ventricular arrhythmia(MVA)after percutaneous coronary intervention(PCI)in patients with acute myocardial infarction.Methods One hundred and seventy-nine patients with acute myocardial infarction who underwent PCI in Anyuan County People's Hospital from June 2020 to June 2023 were selected,patients were divided into MV A group(n=50)and non-MVA group(n=129)according to whether MVA occurred within 72 hour after PCI.The related parameters were obtained by 24-hour dynamic electrocardiogram before operation,and the levels of BNP and CRP were detected.The predictive value of 24-hour dynamic electrocardiogram parameters combined with serum BNP and CRP for MVA after PCI were analyzed by receiver operating characteristic(ROC)curve.Results Twenty-four-hour QT interval variability(24-hour QTV),24-hour normal atrial depolarization to ventricular depolarization time(RR)interval standard deviation(SDNN),24-hour continuous 5 min normal RR interval standard deviation(SDANN-index),24-hour continuous 5 min normal RR interval standard deviation mean(SDNN-index)in MVA group were lower than those in non-MVA group(P＜0.05),serum BNP and CRP levels were higher than those in non-MVA group(P＜0.05).The area under the curve of QTV,SDNN,SDANN-index,SDNN-index,BNP and CRP in predicting MVA after PCI in patients with acute myocardial infarction was 0.723,0.726,0.758,0.762,0.803 and 0.658 respectively,the area under the curve of combined prediction was 0.928,which was higher than that of single prediction.Conclusions The 24-hour QTV,SDNN,SDANN-index and SDNN-index of MVA patients with acute myocardial infarction after PCI are decrease,and the levels of serum BNP and CRP are increase.24-hour dynamic electrocardiogram parameters combine with serum BNP and CRP have high predictive value for MVA risk after PCI.
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