Effects of ivabradine combined with L-carnitine on cardiac function and Sero-associated factor levels in patients with chronic heart failure
Objective To investigate the clinical value of Ivabradine combined with L-carnitine in the treatment of Chronic heart failure(CHF).Methods According to the randomized control principle,136 patients with CHF admitted to our hospital from June 2021 to June 2023 were prospectively selected and divided into control group(n=68)and combination group(n=68)according to 1∶1 ratio.The control group was treated with L-carnitine,and the combination group was treated with Ivabradine combined with L-carnitine.The efficacy of the two groups,before treatment and treatment 15 were compared After d cardiac function indicators[cardiac index(CI),cardiac output(CO),stroke output(SV),left ventricular ejection fraction(LVEF)],vascular endothelial function indicators[nitric oxide(NO),vascular endothelial growth factor(VEGF),endothelin-1(ET-1)]levels,serum related factors[N-terminal brain natriuretic peptide precursor(NT-pr)oBNP),chemokine 12(CXCL12),galactin-3(Gal-3),secreted frizzle-associated protein 5(sFRP5)]levels,incidence of adverse reactions.Results The total effective rate of the combined group(95.59％)(65/68)was higher than that of the control group(85.29％)(58/68)(P＜0.05).After 15 days of treatment,the levels of VEGF,CO,SV,CI,LVEF and NO in combination group were higher than those in control group,and the levels of ET-1 were lower than those in control group(P＜0.05).After 15 days of treatment,the levels of serum NT-proBNP,CXCL12,Gal-3 and sFRP5 in combination group were lower than those in control group(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the combined group(5.88％)(4/68)and the control group(2.94％)(2/68)(P＞0.05).Conclusions Ivabradine combined with L-carnitine in the treatment of CHF patients can effectively reduce the damage of endothelial cells and cardiomyocytes,improve cardiac function and endothelial function,and is safe and reliable,which is conducive to improving the curative effect,controlling the progression of the disease,and promoting the prognosis.
IvabradineL-carnitineChronic heart failureCurative effectHeart function
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