Effects of Dobutamine combined with Fosinopril sodium on cardiac function indexes and oxidative stress response in patients with refractory heart failure
Objective To investigate the application value of Dobutamine combined with Fosinopril sodium in the treatment of Refractory heart failure(RHF).Methods A total of 96 cases of RHF patients admitted to our hospital from January 2020 to June 2023 were retrospectively selected and divided into reference group(n=48)and study group(n=48)according to different treatment methods.Both groups were given conventional symptomatic treatment,on the basis of which the reference group was treated with Fosinopril sodium,and the study group was treated with Dobutamine on the basis of the reference group.Compare the efficacy of the two groups as well as cardiac function indicators(Left Ventricular End-Systolic/Diastolic Diameter,Left Ventricular Ejection Fraction),quality of life score,6-minute step distance,myocardial injury indexes[cardiac troponin T(cTnT),N-terminal brain natriuretic peptide precursor(NT-proBNP)],oxidative stress indexes[myeloperoxidase(MPO),malondialdehyde(MDA),superoxide dismutase(SOD)]before and after treatment and adverse reactions during treatment.Results The total effective rate of the study group(45/48)(93.75％)was higher than that of the control group(38/48)(79.17％)(P＜0.05).After 7 days of treatment,the level of left ventricular ejection fraction in study group was higher than that in reference group,and the level of left ventricular end-diastolic/systolic diameter was lower than that in reference group(P＜0.05).After 7 days of treatment,the MLHFQ score of the study group was lower than that of the reference group(P＜0.05);After 7 days of treatment,the walking distance of 6 min in the study group was longer than that in the control group(P＜0.05).After 7 days of treatment,the levels of NT-proBNP and cTnT in the study group were lower than those in the reference group(P＜0.05).After 7 days of treatment,SOD level of the study group was higher than that of the reference group,MDA and MPO levels were lower than those of the reference group(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the study group(6/48)(12.50％)and the reference group(4/48)(8.33％)(P＞0.05).Conclusions Dobutamine combined with Fosinopril sodium is effective in the treatment of RHF patients,which can effectively inhibit oxidative stress,reduce myocardial injury,improve cardiac function,prolong the 6-min walking distance,and ensure the safety of medication.
DobutamineFosinopril sodiumRefractory heart failureCardiac function indexOxidative stress reactionQuality of life
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