The clinical significance of a three-drug regimen based onticgio and apatinib in the conversion therapy on unresectable elderly patients with advanced gastric cancer
The clinical significance of a three-drug regimen based onticgio and apatinib in the conversion therapy on unresectable elderly patients with advanced gastric cancer
[Objective]To investigate the clinical effect of a three-drug regimen based on Tiggio com-bined with apatinib in the transformational treatment on unresectable advanced gastric cancer in the elder-ly.[Methods]A total of 72 patients with unresectable advanced gastric cancer in our hospital from March 2018 to March 2020 were selected and randomly divided into an observation group of 36 cases and a control group of 36 cases.The observation group was treated with a three-drug regimen based on Tiggio combined with apatinib,and the control group was treated with SOX regimen.Both groups took 3 weeks as a course of treatment,and continued treatment for 2 to 4 courses.The short-term efficacy and quality of life chan-ges,adverse reactions,and progression-free survival(PFS)and overall survival(OS)were compared between the two groups.[Results]The ORR rate in the observation group(77.78％)was higher than that of the con-trol group(55.55％,P＜0.05).The KPS scores of the two groups after chemotherapy were higher than those before chemotherapy(P＜0.05);the KPS scores in the observation group after chemotherapy were higher than those in the control group(P＜0.05).There was no significant difference in bone marrow sup-pression,gastrointestinal reaction and fatigue between the two groups(P＞0.05).All patients were fol-lowed up until January 31,2021 by telephone,WeChat or clinic visit.The median PFS in the observation group was 13 months and the median OS was 19 months;the median PFS in the control group was 8 months,and the median OS was 14 months.The median PFS and OS in the observation group were longer than those in the control group(P＜0.05).[Conclusion]The three-drug regimen based on Tiggio combined with apatinib has a good short-term effect in the conversion therapy in unresectable advanced gastric cancer in the elderly,which can improve the quality of life of patients and prolong the survival time of patients.
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