临床消化病杂志2024,Vol.36Issue(1) :36-38.DOI:10.3870/lcxh.j.issn.1005-541X.2024.01.008

乙肝病毒相关肝硬化并发急性上消化道出血的危险因素分析

Risk factors of acute upper gastrointestinal bleeding in hepatitis B virus-associated cirrhosis

何晓荣 田尧 马林 吉华亮 葛桂萍
临床消化病杂志2024,Vol.36Issue(1) :36-38.DOI:10.3870/lcxh.j.issn.1005-541X.2024.01.008

乙肝病毒相关肝硬化并发急性上消化道出血的危险因素分析

Risk factors of acute upper gastrointestinal bleeding in hepatitis B virus-associated cirrhosis

何晓荣 1田尧 1马林 1吉华亮 1葛桂萍2
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作者信息

  • 1. 南通大学附属海安医院消化内科,江苏南通 226600
  • 2. 南通市中医院消化内科,江苏南通 226610
  • 折叠

摘要

[目的]研究乙肝病毒(HBV)相关肝硬化合并急性上消化道出血的危险因素,以期为临床诊治提供参考.[方法]将258例HBV相关肝硬化患者,按照是否合并急性上消化道出血分为研究组(142例,出血者)、对照组(116例,未出血者).应用单因素分析HBV相关肝硬化合并急性上消化道出血的相关因素,再利用多因素Logistic分析对上述有差异的统计学资料进行进一步回归分析,最终探讨影响HBV相关肝硬化合并急性上消化道出血的危险因素.[结果]单因素分析显示,肝功能分级、凝血酶原时间、胃左静脉内径及血红蛋白为HBV相关肝硬化合并急性上消化道出血的危险因素,差异有统计学意义(P<0.05);多因素分析表明,肝功能分级、凝血酶原时间及胃左静脉内径为影响HBV相关肝硬化并急性上消化道出血的独立危险因素.[结论]HBV相关肝硬化合并急性上消化道出血的危险因素中肝功能分级、凝血酶原时间及胃左静脉内径为其独立危险因素.

Abstract

[Objective]To study the risk factors of acute upper gastrointestinal bleeding in hepatitis B vi-rus(HBV)-related cirrhosis,so as to provide reference for clinical diagnosis and treatment.[Methods]A to-tal of 258 patients with HBV-related cirrhosis admitted to our hospital from July 2016 to July 2021 were retrospectively analyzed.According if they were complicated with acute upper gastrointestinal bleeding,they were divided into bleeding group(study group,142 cases)and non-bleeding group(control group,116 cases).Univariate analysis was used to analyze the risk factors of HBV-associated cirrhosis complicated with acute upper gastrointestinal bleeding,and multivariate Logistic analysis was used to further regression analysis of the above statistical data to finally explore the risk factors of HBV-associated cirrhosis compli-cated with acute upper gastrointestinal bleeding.[Results]Univariate analysis showed that liver function grade,prothrombin time,left gastric vein passage and hemoglobin were risk factors for HBV-related cirrho-sis complicated with acute upper gastrointestinal bleeding,and the differences were statistically significant(P<0.05).Multivariate analysis,which included statistical differences in the above univariate analysis,showed that liver function grade,prothrombin time,and left gastric vein passage were independent risk fac-tors for HBV-related cirrhosis with acute upper gastrointestinal bleeding.[Conclusion]Hepatic function grade,prothrombin time and left gastric vein meridian are independent risk factors for HBV-related cirrho-sis complicated with acute upper gastrointestinal bleeding.

关键词

肝硬化/乙肝病毒/急性上消化道出血/危险因素分析

Key words

related cirrhosis/hepatitis B virus/acute upper gastrointestinal bleeding/risk factor analysis

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基金项目

江苏省中医药科技发展计划(2020)(YB2020066)

南通市卫生计生委科研项目(2023)(MS2023100)

出版年

2024
临床消化病杂志
华中科技大学同济医学院协和医院,中国协和医科大学协和医院

临床消化病杂志

CSTPCD
影响因子:1.085
ISSN:1005-541X
参考文献量9
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