[Objective]To study the distribution and drug resistance of pathogenic bacteria in elderly pa-tients with gastric cancer complicated with diabetes after operation,in order to provide reference for the di-agnosis and treatment of infection.[Methods]The clinical data of 734 elderly patients with gastric cancer complicated with diabetes were retrospectively analyzed.The bacteria collected from the patient samples were isolated and cultured,and the drug sensitivity test of Gram-negative bacteria was carried out by GP method,and the drug sensitivity test of Gram-positive bacteria was carried out by GN201 method.[Results]The totals of 136 cases of elderly patients with gastric cancer complicated with diabetes were infected after operation(infection rate 18.52％).A total of 158 strains of pathogenic bacteria were isolated and cultured from the patients,including 96 strains of Gram-negative bacteria(60.76％),58 strains of Gram-positive bacteria(36.71％)and 4 strains of fungi(2.53％).Among the major gram-positive bacteria,the drug resist-ance rates of Staphylococcus epidermidis to penicillin and erythromycin were 100.00％and 77.78％,re-spectively,and those of Staphylococcus aureus to penicillin and erythromycin were 91.67％and 83.33％,respectively.Among the major gram-negative bacteria,the drug resistance rates of Escherichia coli to cefe-tazidime and levofloxacin were 93.33％and 80.00％,respectively,the drug resistance rates of Klebsiella pneumoniae to cefoperazone and ciprofloxacin were 76.92％and 69.23％,respectively,and the drug resist-ance rates of Pseudomonas aeruginosa to levofloxacin were 80.00％.[Conclusion]The postoperative infec-tion rate of elderly patients with gastric cancer complicated with diabetes is high,the distribution of patho-genic bacteria is mainly Gram-negative bacteria,and the drug resistance rate of cefoperazone,cefetazidime and levofloxacin is high,which is worthy of reference in clinical infection diagnosis and treatment.
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