[Objective]To analyze the application value of linaclotide in bowel preparation before colonoscopy.[Methods]Patients undergoing colonoscopy were randomly divided into two groups for bowel preparation:linaclotide group and control group.Linaclotide 290μg+2 L polyethylene glycolelectrolyte were used for patients of linaclotide group,and 3 L polyethylene glycolelectrolyte were used for patients of control group.Patients'information,subjective feelings and adverse reactions during bowel preparation,numbers of bowel movements,and last stool characteristics were collected.Cleanliness and foaminess of ev-ery segment of the intestine were scored by colonoscopy operators using the single-blind principle.The SPSS23.0 software was used for statistical analysis of the indicators in the two groups.[Results]There were 319 patients in linaclotide group and 334 patients in control group.There was no statistical difference in the total number of defecation between two groups,and the defecation numbers in linaclotide group was significantly higher than that of control group.There were no statistical difference in the cleanliness scores of ascending colon,transverse colon,descending colon,and the total cleanliness of all intestinal segment be-tween two groups.The incidence of nausea,dizziness,and dry mouth was significantly lower in linaclotide group than that in control group.In the linaclotide group,the average daily stool frequency was negatively correlated with the cleanliness of the descending colon and rectum,while the cleanliness of each segment of the intestine was significantly correlated with the cleanliness of the last stool.[Conclusion]There is auxilia-ry application value of linaclotide in bowel preparation by reducing the dose of bowel preparation drugs,wa-ter consumption and the discomfort.Linaclotide can promote the comfort of bowel preparation.
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