[Objective]The objective of this study was to evaluate the efficacy of esomeprazole combined with trifluthixene/melittrix versus esomeprazole alone in the treatment of erosive gastritis with negative emotions.[Methods]The totals of 140 erosive gastritis patients with negative emotions were included in this study.The control group received esomeprazole in 70 cases,and the observation group received esome-prazole plus trifluthixol/melitracen in 70 cases.The course of treatment was 4 weeks.Clinical symptoms,gastric mucosal erosion,prostaglandin E2(PGE2)and malondialdehyde levels,anxiety,depression and recur-rence were observed before and after treatment.[Results]After treatment,the clinical symptoms,mucosal erosion,Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA)scores of the observa-tion group were lower than those of the control group(P＜0.05),PGE2 was higher than that of the control group(P＜0.05),and malondialdehyde(MDA)was lower than that of the control group(P＜0.05).At 6 months follow-up period(100％follow-up rate),16 patients(22.9％)and 34 patients(48.6％)in the obser-vation group and control group relapsed,respectively(P＜0.05).[Conclusion]Esomeprazole combined with trifluthixene/Melitripacin can improve the clinical symptoms and mucosal erosion,relieve the negative mood in erosive gastritis patients,and reduce the recurrence rate.
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