摘要
[目的]探讨老年小切口胃癌患者肠内营养相关性腹泻的影响因素.[方法]选择300例行肠内营养的老年小切口胃癌患者作为研究对象,分析肠内营养相关性腹泻发生情况.采用多因素Logistic回归分析影响老年小切口胃癌患者肠内营养相关性腹泻危险因素,观察因素包括性别、合并基础疾病、禁食时间、低蛋白血症、机械通气、应用镇痛剂、应用抗生素、肠内营养制剂温度.[结果]300例老年小切口胃癌患者中,发生肠内营养相关性腹泻127例,发生率为42.33％.单因素分析表明,肠内营养相关性腹泻组与无相关性腹泻组性别、机械通气和应用镇痛剂比较差异无统计学意义(P＞0.05);2组合并基础疾病、进食时间、低蛋白血症、应用抗生素和肠内营养制剂温度比较差异有统计学意义(P＜0.05).将上述单因素分析差异具有统计学意义的纳入多因素Logistic回归分析显示,禁食时间、低蛋白血症、应用抗生素和肠内营养制剂温度为影响肠内营养相关性腹泻危险因素.[结论]研究显示禁食时间、低蛋白血症、应用抗生素和肠内营养制剂温度为影响老年小切口胃癌患者肠内营养相关性腹泻的危险因素.
Abstract
[Objective]To explore the influencing factors of enteral nutrition-related diarrhea in elderly patients with small incision gastric cancer.[Methods]The total of 300 elderly patients with small incision gastric cancer were selected as the study subjects,and the incidence of enteral nutrition-related diarrhea was analyzed.Multivariate logistic regression analysis was used to analyze the risk factors of enteral nutrition-related diarrhea in elderly patients in intensive care unit.The observed factors included gender,combined with underlying diseases,fasting time,hypoproteinemia,mechanical ventilation,analgesics,antibiotics and enteral nutrition preparation temperature.[Results]Among the 300 elderly patients in ICU,127 had enteral nutrition-related diarrhea,the incidence was 42.33％.Univariate analysis showed that there was no signifi-cant difference in gender,mechanical ventilation and analgesic application between the two groups(P＞0.05);there was significant difference in the temperature of combined basic diseases,feeding time,hy-poproteinemia,antibiotics and enteral nutrition preparations between the two groups(P＜0.05).The logis-tic regression analysis showed that fasting time,hypoproteinemia,antibiotics and enteral nutrition prepara-tion temperature were risk factors for enteral nutrition-related diarrhea.[Conclusion]Multicenter analysis suggests that fasting time,hypoproteinemia,application of antibiotics and temperature of enteral nutrition preparations are the risk factors for enteral nutrition-related diarrhea in elderly patients with small incision gastric cancer in intensive care unit.
基金项目
2022年度河北医学科学研究课题计划(20220217)
NETL
NSTL
万方数据