摘要
[目的]分析消化系统疾病患者高同型半胱氨酸(高血同)患病率的基线资料,为临床干预及进一步研究提供基础数据支持.[方法]建立消化系统疾病患者血同数据库,采用Spearman秩相关分析血同与消化系统疾病相关性;将患者按照部位与是否存在消化系统肿瘤分组,对各组患者血同资料进行统计描述并计算患病率.采用Mann-Whitney U检验,以急性阑尾炎组为对照组,分别对比肝脏疾病、胆囊疾病、胰腺疾病、上消化道疾病、结直肠疾病血同差异;对比消化系统肿瘤与非肿瘤性消化系统疾病血同差异,对所有患者按照血同异常程度赋分并对比2组高血同异常程度.[结果]血同与消化系统疾病相关性分析示P=0.005,rs=0.069;消化系统疾病患者高血同总患病率91.15％,其中消化系统肿瘤96.02％、非肿瘤性消化系统疾病90.36％;各组患病率分别为肝脏疾病92.97％、胆囊疾病92.09％、胰腺疾病85.72％、上消化道疾病91.66％、结直肠疾病93.81％、急性阑尾炎78.26％.消化系统疾病及各组患者血同均为非正态计量资料,消化系统疾病患者血同为15.10(12.10～18.80)μmol/L,其中消化系统肿瘤组15.95(12.80～21.75)μmol/L、非肿瘤性消化系统疾病组15.10(12.00～18.60)μmol/L;各组血同分别为肝脏疾病组15.60(12.60～20.15)μmol/L、胆囊疾病组14.80(11.725～19.35)μmol/L、胰腺疾病组15.25(11.30～19.90)μmol/L、上消化道疾病组 15.10(12.30～18.50)μmol/L、结直肠疾病组 15.70(12.80～18.60)μmol/L、急性阑尾炎组12.60(10.20～17.25)μmol/L.急性阑尾炎组与胰腺疾病组血同无统计学差异(Z=-1.891,P=0.059);急性阑尾炎组分别与肝脏疾病组(Z=-3.155,P=0.002)、胆囊疾病组(Z=-2.472,P=0.013)、上消化道疾病组(Z=-2.732,P=0.006)、结直肠疾病组(Z=-3.333,P=0.001)血同比较有统计学差异(P＜0.05).消化系统肿瘤组与非肿瘤性消化系统疾病组血同(Z=-2.958,P=0.003)与其异常程度(Z=-2.082,P=0.037)比较差异有统计学意义(P＜0.05).[结论]消化系统疾病患者高血同患病率高,血同与消化系统疾病存在正相关性,肝脏疾病、胆囊疾病、上消化道疾病、结直肠疾病与高血同相关性更大.
Abstract
[Objective]The baseline data on hyperhomocysteinemia prevalence of patients with digestive diseases can provide basic data support for clinical intervention and further research.[Methods]A database of homocysteine in patients with digestive system diseases was established,Spearman rank correlation was used to analyze the correlation between homocysteine and digestive diseases.Patients were grouped by parts and presence or absence of digestive system tumors,homocysteine data of each group of patients were statistically described and the prevalence was calculated.By using Mann-Whitney U test,the acute appendi-citis group was set as the control group,homocysteine differences in liver disease,gallbladder disease,pan-creatic disease,upper gastrointestinal disease,and colorectal disease were compared respective-ly.Homocysteine differences between digestive system tumors and non-tumor digestive diseases were com-pared,all patients were assigned according to the degree of homocysteine abnormalities and compared the two groups with the degree of hyperhomocysteinemia.[Results]Correlation analysis of homocysteine and digestive system diseases(P=0.005,rs=0.069),total prevalence of Hyperhomocysteinemia patients with digestive diseases was 91.15％,digestive tumors was 96.02％,non-neoplastic digestive disorders 90.36％.The prevalence of liver disease was 92.97％,gallbladder disease was 92.09％,pancreatic disease was 85.72％,upper digestive tract disease was 91.66％,colorectal disease was 93.81％,and acute appendicitis was 78.26％.Digestive system diseases and homocysteine in all groups of patients were non-normal meas-urement data,the homocysteine patients with digestive system disease was 15.10(12.10-18.80)μmol/L,the digestive system tumor group was 15.95(12.80-21.75)μmol/L,non-tumor digestive disease group 15.10(12.00-18.60)μmol/L.Homocysteine in other groups:liver disease group was 15.60(12.60-20.15)μmol/L,gallbladder disease group was 14.80(11.725-19.35)μmol/L,pancreatic disease group was 15.25(11.30-19.90)μmol/L,upper digestive tract disease group was 15.10(12.30-18.50)μmol/L,colo-rectal disease group was 15.70(12.80-18.60)μmol/L,acute appendicitis group was 12.60(10.20-17.25)μmol/L.There was no homocysteine statistically difference between the acute appendicitis group and pan-creatic disease group(Z=-1.891,P=0.059).There was homocysteine statistically difference between a-cute appendicitis group and liver disease group(Z=-3.155,P=0.002),gallbladder disease group(Z=-2.472,P=0.013),upper digestive tract disease group(Z=-2.732,P=0.006),colorectal disease group(Z=-3.333,P=0.001;all P＜0.05).There was statistically difference between the homocysteine of di-gestive system tumor group and non-tumor digestive disease group(Z=-2.958,P=0.003)contrast to its abnormal degree(Z=-2.082,P=0.037;all P＜0.05).[Conclusion]Hyperhomocysteinemia prevalence is high in patients with digestive diseases,there is a positive correlation between homocysteine and digestive diseases.Liver disease,gallbladder disease,upper digestive tract disease and colorectal disease all have high correlation with hyperhomocysteinemia.
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万方数据