艾司奥美拉唑方案治疗慢性胃炎患者反流的临床研究
Esomeprazole regimen for reflux symptoms in patients with chronic gastritis
徐成龙 1程海俐 1张彩凤 1吴国斌2
作者信息
- 1. 沧州市人民医院本部消化内科二区,河北沧州 061000
- 2. 石家庄市人民医院消化内科,河北石家庄 061100
- 折叠
摘要
[目的]对比艾司奥美拉唑2周与8周方案对胃镜检查阴性的非糜烂性反流病和慢性胃炎患者的疗效,以期为临床诊治提供参考.[方法]将反流病和慢性胃炎患者均给予艾司奥美拉唑20 mg、1次/d,采用8周或2周方案.主要终点是维持/按需治疗期第24周的症状控制率,次要终点是症状缓解率、成功率(定义为在初始治疗和维持治疗24周后症状缓解的患者)、首次复发时间和满意率.[结果]8周方案(8周组)对比2周方案(2周组)的症状控制率差异有统计学意义(94.9％比87.3％,P=0.0473).在次级终点中,8周组在最初的艾司奥美拉唑治疗后症状缓解效果略好于2周组(88.3％比83.4％,P=0.2513),2组整个研究的成功率比较P=0.0258(83.8％比72.8％).与2周组相比,8周组的复发风险降低了 46％(HR=0.543;95％CI:0.388～0.761).2组之间的安全性相当,2种方案耐受性均很好.[结论]非糜烂性反流病患者使用8周方案较慢性胃炎患者2周方案反流症状的控制略好一些,安全性相似.
Abstract
[Objective]To compare the efficacy of esomeprazole regimen in patients with endoscopic diag-nosed non-erosive reflux disease and chronic gastritis with,so as to provide reference for clinical diagnosis and treatment.[Methods]Patients with reflux disease and chronic gastritis were given esomeprazole 20 mg once daily for an 8-week or 2-week regimen.The primary endpoint was symptom control rate at week 24 of the maintenance/on demand treatment period,and secondary endpoints were symptom remission rate,suc-cess rate(defined as patients whose symptoms resolved after 24 weeks of initial treatment and maintenance treatment),time to first recurrence,and satisfaction rate.[Results]There was significant difference in symptom control rate between the 8-week regimen and the 2-week regimen(94.9％vs 87.3％,P=0.0473).Among secondary endpoints,the 8 wk group had slightly better symptom relief after initial es-omeprazole treatment(88.3％vs 83.4％,P=0.2513)and success rates across the study(83.8％vs 72.8％,P=0.0258).The risk of recurrence was 46％lower in the 8-week regimen compared to the 2-week regimen(HR=0.543;95％CI:0.388-0.761).Safety was comparable between the two groups,and both regimens were well tolerated.[Conclusions]In patients diagnosed with chronic gastritis,an 8-week esomeprazole regi-men compared with a 2-week esomeprazole regimen resulted in slightly better control of reflux symptoms and similar safety.
关键词
非糜烂性反流病/艾司奥美拉唑/慢性胃炎方案/症状控制率Key words
non erosive reflux disease/esomeprazole/chronic gastritis protocol/symptom control rates引用本文复制引用
基金项目
河北省2023年度医学科学研究课题计划(20231603)
2021年沧州市科技计划自筹经费项目(213106029)
出版年
2024
NETL
NSTL
万方数据