摘要
[目的]探讨老年帕金森病(PD)前驱期消化不良的临床特征及影响因素.[方法]选择老年PD前驱期患者160例作为研究对象.采用安德森症状评估量表中文版(MDASI-C)评估患者消化不良,根据是否发生消化不良分为消化不良组和无消化不良组.采用单因素分析影响老年PD前驱期消化不良相关因素;采用多因素Logistic回归分析影响老年PD前驱期消化不良独立危险因素.收集资料包括性别、年龄、吸烟史、饮酒史、受教育年限、高血压病史、糖尿病病史、葡萄糖水平、血尿酸、血浆同型半胱氨酸(Hcy).[结果]PD前驱期患者中,发生消化不良患者46例,发生率为28.75％.单因素分析显示,消化不良组与无消化不良组性别、年龄、吸烟史、饮酒史、高血压病史和糖尿病病史比较差异无统计学意义(P＞0.05),消化不良组与无消化不良组受教育年限、葡萄糖水平、血尿酸和血浆Hcy比较差异有统计学意义(P＜0.05).将上述单因素分析具有统计学意义的纳入多因素Logistic回归分析显示,受教育年限、葡萄糖水平、血尿酸和血浆Hcy为影响PD前驱期患者消化不良独立危险因素.[结论]老年PD前驱期患者消化不良发生率较高,且受多因素影响,受教育年限、葡萄糖水平、血尿酸和血浆Hcy为其独立危险因素.
Abstract
[Objective]To investigate the clinical characteristics and impact of dyspepsia in the prodromal phase of Parkinson's disease(PD)in elderly patients..[Methods]The totals of 160 elderly PD prodromal patients from December 2018 to December 2020 in our hospital were selected as the study subjects.The Chinese version of Anderson symptom assessment scale(mdasi-c)was used to evaluate patients'dyspepsia,and they were divided into dyspepsia group and no dyspepsia group according to whether dyspepsia oc-curred or not.Univariate analysis was used to identify factors associated with dyspepsia in the prodromal phase of PD in the elderly;Multivariate logistic regression was used to analyze the independent risk factors affecting dyspepsia in the prodromal phase of PD in the elderly patients.Data collected included sex,age,smoking history,drinking history,years of education,history of hypertension,history of diabetes mellitus,glucose level,serum uric acid,and plasma homocysteine(Hcy).[Results]Among PD prodromal patients,dyspepsia occurred in 46 cases,with an incidence of 28.75％.Univariate analysis showed that the differ-ences of gender,age,smoking history,drinking history,hypertension history,and diabetes mellitus history were not statistically significant between patients with and without dyspepsia(P＞0.05).Differences of ed-ucation level,glucose levels,serum uric acid,and plasma Hcy were statistically significant(P＜0.05)be-tween patients with and without dyspepsia.The inclusion of the above univariate analysis with statistical significance in the multivariate logistic regression analysis revealed education level,glucose levels,serum u-ric acid,and plasma Hcy as independent risk factors for dyspepsia in the prodromal phase of PD.[Conclu-sion]Elderly patients in the prodromal phase of PD have a high incidence of dyspepsia and are multifactori-al,with years of education,glucose levels,serum uric acid,and plasma Hcy as independent risk factors.
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