夜间睡眠、午睡习惯与胃食管反流病的相关性研究
A study on the correlation between nocturnal sleep napping habits and gastroesophageal reflux disease
吴妙荣 1王雯 2王宝珊 2柳刚2
作者信息
- 1. 福建医科大学福总临床医学院,福建 福州 350025
- 2. 福建医科大学福总临床医学院,福建 福州 350025;中国人民解放军联勤保障部队第九○○医院消化内科,福建 福州 350025
- 折叠
摘要
[目的]探索夜间睡眠、午睡习惯与胃食管反流病(GERD)的相关性.[方法]采用病例对照研究,将180例具有烧心和(或)反流症状且GerdQ评分≥8分、或胃镜发现反流性食管炎(RE)的患者纳入GERD组,同期入院363例体检者(胃镜排除RE且GerdQ评分＜8分)纳入对照组.采用t检验或x2检验分析2组研究对象的基本资料,使用Logistic回归先后进行单因素、多因素分析.[结果]GERD组与对照组的饮酒、进食过饱、夜间睡前进食、夜间入睡时间、夜间睡眠时间、午餐与午睡间隔时间方面比较,差异有统计学意义.多因素Logistic回归分析显示:饮酒、夜间睡前进食、夜间入睡晚、夜间睡眠时间短与GERD风险升高相关(OR=2.13,95％CI=1.12～4.07;OR=1.84,95％CI=1.19～2.84;OR=1.31,95％CI=1.02～1.67;OR=1.33,95％CI=1.04～1.69).对有午睡习惯者进行多因素Logistic回归分析发现,午餐与午睡间隔时间短与GERD风险升高相关(OR=1.74,95％CI1.17～2.59).[结论]饮酒、夜间睡前进食、夜间入睡晚、夜间睡眠不足是GERD发病的危险因素.在有午睡习惯者中,午餐与午睡间隔时间短可增加GERD发病风险.
Abstract
[Objective]To explore the correlation between nocturnal sleep,napping habits and gastroe-sophageal reflux disease(GERD)..[Methods]In a case-control study,180 patients with heartburn and/or reflux symptoms and GerdQ score≥8,or gastroscope detected reflux esophagitis(RE)were included in the GERD group,and 363 patients with gastroscope excluded RE and GerdQ score＜8 were included in the con-trol group during the same period.T test orx2 test was used to analyze the basic data of the two groups of subjects,and logistic regression was used to conduct univariate and multivariate analysis successively.[Re-sults]There were statistically significant differences between the two groups in drinking,overeating,eating at night before bed,time to fall asleep at night,sleep duration at night,and time between lunch and nap.Multivariate logistic regression analysis showed that alcohol consumption,eating before bedtime at night,falling asleep late at night,and short sleep duration at night were associated with increased risk of GERD(OR=2.13,95％CI=1.12-4.07;OR=1.84,95％CI=1.19-2.84;OR=1.31,95％CI=1.02-1.67;OR=1.33,95％CI=1.04-1.69).Multivariate logistic regression analysis of napping habits found that a shorter interval between lunch and napping was associated with an increased risk of GERD(OR=1.74,95％CI=1.17-2.59).[Conclusion]Drinking,eating at night before bed,falling asleep late at night and insufficient sleep at night are risk factors for GERD.A short interval between lunch and napping was associated with an increased risk of GERD among napping habits subjects.
关键词
胃食管反流病/胃食管反流病问卷/危险因素/夜间睡眠Key words
gastroesophageal reflux disease/gastroesophageal reflux disease questionnaire/risk factors/nocturnal sleep引用本文复制引用
出版年
2024
NETL
NSTL
万方数据