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牙源性始基瘤4例临床病理学观察

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目的 探讨牙源性始基瘤(primordial odontogenic tumour,POT)的临床病理学特征、诊断和鉴别诊断.方法 收集4例颌骨POT的临床资料,采用影像学检查、HE和免疫组化EnVision两步法染色,分析其临床病理特征并复习相关文献.结果 4例患者发病年龄5~21岁;男女性各2例;发病部位于上、下颌骨各2例.临床表现为缓慢生长的无痛性肿块,切面呈灰黄、灰白色,周围多与1枚未萌牙牙冠相关.肿瘤由黏液样背景中散在疏松梭形或星形细胞组成,周边可见单层立方、柱状上皮被覆,部分区域可见乳头状反褶内陷,2例可见钙化.结论 POT是罕见的良性牙源性混合性肿瘤,好发于儿童和青少年.掌握其特征性的组织学表现可作出正确诊断,行完整切除者预后良好.
Clinical and pathological observation of 4 cases of odontogenic primordial tumors
Purpose To investigate the clinicopathological features,diagnosis and differential diagnosis of the primordial odontogenic tumour(POT).Methods Clinical data of 4 cases of jawbone POT were collected.Imaging examination,HE,and immunohistochemical EnVision two-step staining was used to an-alyze their clinical and pathological characteristics,and relevant literatures were reviewed.Results The age arranged from 5 years to 21 years.2 cases were male and 2 case were female.There were 2 cases in maxilla and 2 cases in mandible.The clinical presentation was a slow growing painless mass.Cut sur-face of the tumor was appeared grayish yellow and grayish white,the tumor involved the crown of an unerupted tooth.The tumour consisted of a proliferation of spindled and stellate cells in myx-oid stroma.Surfaced by cuboidal to columnar epithelium forming papillary structures and invaginations.Calcification was observed in 2 cases.Conclusion POT is a rare benign mixed odontogen-ic tumor that is more common in children and adolescents.Mas-tering its characteristic histological morphology can make a cor-rect diagnosis.Local complete resection of the tumor has a good prognosis.

odontogenic neoplasmprimordial odontogenic tumourclinicopathological featuresimmunohistochemistryprognosis

张磊、李慧玲、夏舒、帕克扎提·色依提、陈盛、杨艳、叶传进、泥艳红、黄晓峰

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南京大学医学院附属口腔医院/南京市口腔医院/南京大学口腔医学研究所口腔病理科,南京 210008

南京大学医学院附属口腔医院/南京市口腔医院/南京大学口腔医学研究所口腔颌面医学影像科,南京 210008

南京大学医学院附属口腔医院/南京市口腔医院/南京大学口腔医学研究所中心实验室,南京 210008

牙源性肿瘤 牙源性始基瘤 病理学特征 免疫表型 预后

国家自然科学基金南京大学医学院附属口腔医院"3456"骨干人才资助项目

82173159222E309

2024

临床与实验病理学杂志
安徽医科大学,中华医学会安徽分会

临床与实验病理学杂志

CSTPCD北大核心
影响因子:0.776
ISSN:1001-7399
年,卷(期):2024.40(7)
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