非典型梭形细胞脂肪瘤样肿瘤8例临床病理特征
Clinicopathological characteristics of atypical spindle cell lipomatous tumours:report of eight cases
周冬梅 1卢建平 2张静 2何时 2杨世娟2
作者信息
- 1. 福建医科大学肿瘤临床医学院/福建省肿瘤医院病理科,福州 350014;福建医科大学肿瘤临床医学院/福建省肿瘤医院福建省转化医学重点实验室,福州 350014
- 2. 福建医科大学肿瘤临床医学院/福建省肿瘤医院病理科,福州 350014
- 折叠
摘要
目的 探讨非典型梭形细胞脂肪瘤样肿瘤(atypical spindle cell lipomatous tumour,ASLT)的临床病理学特征.方法 回顾性分析8例ASLT的临床病理、免疫表型及分子特征,采用免疫组化EnVision两步法和FISH对8例ASLT进行检测,并复习相关文献.结果 8例均可见不同比例的梭形细胞、脂肪细胞混杂分布,细胞无或轻度异型,无坏死.免疫表型:8例肿瘤细胞CD34、S-100不同程度阳性,RB均表达缺失,MDM2、CDK4阴性或灶阳性,Ki67增殖指数低.FISH检测示6例MDM2无扩增.结论 ASLT是新近命名的良性脂肪源性肿瘤亚型,具有独特的形态学、免疫表型及分子特征,预后好,正确诊断可避免临床过度治疗.
Abstract
Purpose To explore the clinicopathological characteristics of atypical spindle cell lipomatous tumour(ASLT).Methods The clinical pathology,immunopheno-type,and molecular characteristics of 8 ASLTs diagnosed and treated in Fujian Cancer Hospital from 2020 to 2023 were col-lected.The histological morphology,immunophenotype and mo-lecular characteristics of 8 ASLTs were evaluated by HE stai-ning,immunohistochemistry and FISH.Clinicopathological fea-tures of 8 ASLTs were analyzed with literature review.Results Mixed distribution of spindle cells and adipocytes in different proportions was seen in all 8 cases,with no or mild cell atypia and no necrosis.Immunophenotypically,8 ASLTs were CD34 and S-100 positive to varying degrees,RB was negative,MDM2 and CDK4 were negative or focus positive,and Ki67 prolifera-tion index was low.FISH showed MDM2 amplification was nega-tive in 6 cases.Conclusion ASLT is a newly named benign adipose-derived tumor subtype with unique morphology,immu-nophenotype,and molecular characteristics.It has a good prog-nosis.Correct diagnosis can avoid clinical over-treatment.
关键词
脂肪源性肿瘤/梭形细胞脂肪瘤样肿瘤/RB/MDM2扩增Key words
adipose-derived tumors/spindle cell lipomatous tumors/RB/MDM2 amplification引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据