Trop2 and β-catenin expression in triple negative breast cancer and relationship with clinicopathological characteristics and prognosis
Purpose To investigate the expression of Trop2 and β-catenin in triple negative breast cancer(TNBC)and to explore their relationship with clinicopathologic features and prognosis.Methods Clinicopathologic features and prognosis of TNBC patients were collected.TNBC was classified into HER2-low(1+,2+FISH negative)and 0 expression.The expression of Trop2 and β-catenin in tumors was evaluated by immunohistochemistry in paraffin embedded tissue.The correla-tion between Trop2,β-catenin expression and clinicopathologic features and prognosis was analyzed.Results Among 180 ca-ses of TNBC,there were 60.6％(109/180)high Trop2 expres-sion and 71.7％(129/180)abnormal β-catenin expression,and 48.9％(88/180)co-expression.Chi-square test showed compared with Trop2-low TNBC patients,Trop2-high TNBC pa-tients had high abnormal expression rate of β-catenin(80.7％vs 57.7％,P＜0.001).TNBC patients with Trop2-high or β-catenin abnormal expression had higher AJCC stage(P=0.006,P=0.001),distant metastasis(P=0.005,P=0.006),and lower HER2-low(P=0.009,P=0.005).TNBC patients with Trop2-high had higher lymph node metastasis(P=0.031)and lower age＜50 years(P=0.035).TNBC patients with β-catenin abnormal expression had higher histological grade(P=0.014).The median follow-up time was 69.5 months,3.3％(6/180)were lost to follow-up,36.1％(65/180)re-lapsed,and 19.4％(35/180)died.Survival analysis showed that Trop2-high(P=0.017,P=0.001),β-catenin positive(P=0.030,P=0.007)and Trop2(high)/HER2(0)/β-catenin(abnormal)(P＜0.001)had shorter disease-free survival(DFS)and over-all survival(OS).Cox regression a-nalysis showed that the patients with high AJCC stage(HR=2.543,P＜0.001)and basal-like TNBC(HR=3.948,P=0.024),Trop2(high)/HER2(0)/β-catenin(abnormal)(HR=4.452,P＜0.001)had a higher mortality risk,but TILs≥ 30％(HR=0.341,P=0.044)had a lower mortality risk.Conclusion The expression of Trop2,β-catenin and HER2 were correlated in TNBC.Trop2(high)/HER2(0)/β-catenin(abnormal),can predict prognosis.
breast neoplasmtriple-negative breast cancerTrop2β-cateninHER2prognosis
万方数据
维普
