拉莫三嗪联合帕罗西汀治疗双相抑郁的临床疗效及安全性
Effect and Safty Lamotrigine Combined with Paroxetine in Treatment of Bipolar Depression
劳成明1
作者信息
- 1. 浙江省义乌市精神卫生中心精神科 浙江义乌 322000
- 折叠
摘要
目的：探讨拉莫三嗪联合帕罗西汀治疗双相抑郁的临床疗效及安全性。方法：将118例双相抑郁患者随机分入对照组(58例)与观察组(60例)，给予对照组患者帕罗西汀口服治疗，观察组患者接受拉莫三嗪联合帕罗西汀口服，疗程8周。治疗前后采用汉密尔顿抑郁量表（HAMD）及临床总体印象量表(CGI)评估疗效。结果：治疗后8周，观察组治疗有效率显著高于对照组（88.3%（53/60）对70.7%（41/58），P<0.05）；观察组HAMD认知障碍、焦虑/躯体化、阻滞以及睡眠障碍因子显著优于对照组(P<0.05)；观察组CGI评分显著低于对照组(P<0.05)；两组不良反应无显著性差别。结论：拉莫三嗪联合帕罗西汀治疗双相抑郁临床疗效确切，且不增加不良反应。
Abstract
Objective: To explore the effect and safty of lamotrigine combined with paroxetine in treatment of bipolar depression. Methods 118 cases with bipolar depression were randomly divided into control group(n=58) and experience group(n=60). Control group were given paroxetine and experience group received lamotrigine combined with paroxetine. HAMD and CGI scales were used to evaluate the clinical effect. Result After treatment, the effective rate of treatment in experience group(53) was much higher than that in control group(41)(88.3% vs 70.7%(P<0.05); HAMD scales of cognitive disturbance, anxiety/somatization, retardance and sleep disturbance retardance were superior to control group (P<0.05); Comparison with control group, CGI scores in experience group greatly decreased (P<0.05);There were no significant difference of complicate rates between two groups (P>0.05). Conclusions Lamotrigine combined with paroxetine for bipolar depression is effective and safety.
关键词
双相抑郁/拉莫三嗪/帕罗西汀Key words
Bipolar depression/Lamotrigine/Paroxetine引用本文复制引用
出版年
2014
NETL
NSTL
维普
万方数据