Latest advances in antithrombotic therapy for peripheral arterial disease
Peripheral artery disease(PAD)is associated with an increased risk of major adverse limb and cardiovascular events.Antithrombotic therapies including single or dual antiplatelet agents,anticoagulation,or a combination of these treatments have been shown to reduce limb and cardiovascular events.The goals of antithrombotic treatment are to prevent cardiovascular events,to keep vessels open after revascularization,and to lessen the frequency of peripheral ischemia and of amputation.However,the optimal an-tithrombotic regimen and duration of therapy in PAD remain unclear,largely due to a paucity of high-quality randomized controlled trials in the patient population.Recently,there have been important advances further increasing the evidence of antithrombotic choic-es for peripheral artery disease patients,especially the trials of COMPASS and VOYAGER.This paper aims to summarize the current available evidence for the safety and efficacy of various antithrombotic choices,and discuss how to apply rational antithrombotic ther-apy for asymptomatic,symptomatic,percutaneous transluminal angioplasty,and vascular bypass surgical patients with PAD.
NETL
NSTL
万方数据
