A novel influenza virus polymerase inhibitor:ZSP1273
Influenza is an acute respiratory infection caused by influenza virus.Antiviral drugs can shorten the duration of the disease and reduce the occurrence of serious complications.ZSP1273 is a small molecule anti-influenza drug of RNA-de-pendent RNA polymerase(RdRp)polymerase basic 2(PB2)subunit inhibitor of influenza A virus.Phase Ⅲ clinical trial re-sults indicate that ZSP1273 significantly shortens the time for influenza symptom remission and fever resolution compared with placebo.Compared with placebo or oseltamivir,ZSP1273 reduces influenza A viral load faster and more effectively,signifi-cantly shortens the time for viral transition to negative,and shows good safety and tolerability.This article provides an over-view of the basic information,mechanism of action,pharmacokinetics,preclinical research and clinical studies of ZSP1273.
ZSP1273influenza A virusRNA-dependent RNA polymeraseoseltamivir
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