Analysis of influencing factors of postoperative adjuvant chemotherapy compliance in patients with non-small cell lung cancer
Objective To explore the influencing factors of postoperative adjuvant chemotherapy compliance in patients with non-small cell lung cancer(NSCLC).Methods The data of patients with NSCLC treated in Jiangsu Provincial People's Hospital from December 2019 to December 2022 were collected.The original medical records were reviewed and the ques-tionnaire was used to supplement the incomplete data collection.According to chemotherapy compliance,patients were divid-ed into a good compliance group and a poor compliance group,and the influencing factors of chemotherapy compliance were analyzed.At the same time,the causes of chemotherapy interruption and the occurrence of serious ADR in patients with poor chemotherapy compliance were summarized.Results A total of 148 patients were included,including 69 patients in the good compliance group and 79 patients in the poor compliance group.Univariate analysis showed that there were significant differ-ences in age,educational level,pathological type,TNM stage,surgery type and family per capita monthly income between the two groups(P<0.05).Multivariate logistic regression showed that age,education level,pathological type,TNM stage,and surgery type were independent risk factors for chemotherapy compliance in NSCLC patients(P<0.05).Among the 79 pa-tients with poor compliance,the reasons for chemotherapy interruption were serious adverse reactions in 41 cases,rejection in 20 cases,failure to achieve the expected therapeutic effect in 14 cases,and economic reasons in 4 cases.Conclusion Age,education level,pathological type,TNM stage,and surgery type are independent risk factors for chemotherapy compliance in patients with NSCLC.Clinical attention should be paid to this group of patients and active intervention should be conducted to reduce adverse reactions and improve chemotherapy compliance.
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