Analysis of spontaneous reports adverse drug reactions induced by compound reserpine and triamterene tablets
Objective To analyze the spontaneous reports of adverse drug reactions(ADRs)induced by compound reser-prine and triamterene tablets to understand the characteristics of their ADRs,thereby providing references for the clinically safe use of these drugs.Methods ADR reports of compound reserpine and triamterene tablets collected by the National Center for ADR Monitoring between January 2014 and October 2022 were retrieved and sorted out.Statistical analysis was performed on gender,age,system organ class affected,clinical manifestation,and serious cases of the ADRs.Results In the past nine years,a total of 6104 ADR reports were received.The ratio of male to female was 1.20∶1 and below 65 years old to above 65 years,old was 1.57∶1.A total of 9569 events were reported in 6104 cases,mainly involving the nervous system(2792,29.18%),gastrointestinal system(2779,29.04%)and general disorders(1462,15.28%).The main clinical manifestations were nausea(1601,16.73%),dizziness(1078,11.27%)and fatigue(1062,11.10%).There were 165 severe ADR reports(2.70%),102 ADR reports were related to hypotension(1.67%),43 ADR reports were related to depression(0.70%),14 ADR reports were related to gastrointestinal bleeding(0.23%),and 6 ADR reports related to bradycardia(0.10%),in a total of 6104 reports.Conclusion The compound reserpine and triamterene tablets have good safety.In the real world,the clinical manifestations of ADRs caused by compound reserpine and triamterene tablets mainly include nausea,dizziness,and fatigue,while reports of hypotension,depression,gastrointestinal bleeding and bradycardia are extremely low in proportion.
compound reserpine and triamterene tabletsadverse drug reactionssafety
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