布立西坦治疗癫痫的研究进展
Research progress of brivaracetam in the treatment of epilepsy
刘成裕 1刘代华 1李俊明 1曾坤 1覃禹1
作者信息
- 1. 广西医科大学附属柳州市人民医院 药学部,广西 柳州 545006
- 折叠
摘要
药物治疗是癫痫的主要治疗手段,然而传统抗癫痫药物不良反应明显,患者耐受性较差,限制了其在临床中的应用.布立西坦作为第3代新型抗癫痫药物,主要用于局灶性癫痫的添加治疗和单药治疗,也是治疗全面性癫痫和癫痫持续状态的潜在选择.与传统抗癫痫药物相比,布立西坦具有更高的安全性和耐受性.本文综述了布立西坦的作用机制、药动学特征、疗效和安全性,以期为癫痫治疗提供更有效的选择.
Abstract
Pharmacotherapy is the mainstay treatment of epilepsy;however,the significant adverse reactions and poor tolerance associated with traditional antiepileptic drugs limit their clinical application.Brivaracetam,as the third-generation new antiepileptic drug,is mainly indicated for adjunctive therapy and monotherapy for patients with focal epilepsy,and pres-ents a potential option for the treatment of generalized epilepsy and status epilepticus.Compared to the traditional antiepileptic drugs,brivaracetam offers higher safety and tolerability.This article reviews the mechanism of action,pharmacokinetic charac-teristics,efficacy and safety of brivaracetam,aiming to provide more effective choices for the treatment of epilepsy.
关键词
布立西坦/癫痫/添加治疗/单药治疗/疗效/安全性Key words
brivaracetam/epilepsy/adjunctive therapy/monotherapy/efficacy/safety引用本文复制引用
基金项目
广西药学会医院药学科研项目(GXYXH1-202210)
出版年
2024
NETL
NSTL
万方数据