Comparative analysis of efficacy and safety of different dosage forms of paliperidone palmitate in the treatment of schizophrenia
Objective To compare the difference in efficacy and safety between paliperidone palmitate 1-month(PP1M)and paliperidone palmitate 3-month(PP3M).Methods A systematic review of the literature on the efficacy and safety of PP1M and PP3M in relevant Chinese and English databases from CNKI,Wanfang Data,PubMed,Embase,the Cochrane Library and so on,from the inception of the database until November,2023.Results A total of 10 literatures were further screened to meet the exclusion criteria.The subjects of the included literature were all adult schizophrenia patients with a study period ranging from 7 months to 24 months.The results showed that PP1M and PP3M improved the symptoms of patients with schizophrenia to a similar extent.PP3M was more effective than PP1M in reducing the rate of hospitalization for psychiatric disorders and the risk of relapse.The risk of extrapyramidal symptoms(EPS)and weight gain was lower with PP3M than with PP1M,and there was no significant difference in other safety indexes between the two groups.Conclusion The efficacy and safety of PP1M and PP3M were comparable,and the medication compliance of PP3M was better.
NETL
NSTL
万方数据
