Comprehensive clinical evaluation of semaglutide injection for the treatment of diabetes mellitus type 2 in adults
Objective Comprehensive clinical evaluation of semaglutide injection was conducted to provide a reference for clinical decision-making and rational use of this drug.Methods A systematic literature review and questionnaire surveys were used,to perform a qualitative and quantitative analysis of the efficacy,safety,economy,innovation,suitability,and ac-cessibility of the drugs.Results In terms of efficacy and safety,semaglutide significantly reduces glycated hemoglobin A1c(HbA1c)levels,fasting blood glucose,and body weight,while also improving the achievement rate of HbA1c targets.The overall safety of semaglutide injection was good,with a low risk of hypoglycemia,although the risk of gastrointestinal adverse reactions was higher or similar to other antidiabetic drugs.In terms of economy,semaglutide injection demonstrates greater economic advantages compared to dulaglutide and loxenatide.With good clinical innovation,semaglutide injection was recom-mended by clinical guidelines both domestically and internationally.In terms of dosing convenience and compliance,it exhibits good suitability for use.Semaglutide injection exhibits good affordability,but the number of bid-winning areas and the rate of medical institution distribution were relatively low,leading to shortages.Conclusion Semaglutide injection demonstrates good efficacy,safety,economy,innovation,suitability,and affordability.However,its availability needs to be further improved.
semaglutidediabetes mellitus type 2comprehensive clinical evaluationglucagon-like peptide-1
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