Effects of different administration methods of octreotide on intestinal mucosal permeability and hemorheology in patients with acute pancreatitis
Objective To explore the effects of different administration methods of octreotide on intestinal mucosal permeability and hemorheology in patients with acute pancreatitis.Methods Patients with acute pancreatitis in the Henan Province Third People's Hospital from February 2021 to October 2022 were selected as the study objects and were randomly divided into the control group and the observation group,both receiving octreotide treatment.The control group received a routine intravenous drip,while the observation group received an intravenous micropump.The efficacy and the adverse reactions between the two groups and compared the changes in intestinal mucosal functional indicators,hemorheological indicators,and inflammatory factors,between the two groups before and after treatment were observed.Results A total of 106 patients were included,with 53 in each group.After treatment,the levels of diamine oxidase(DAO),D-lactate,lactulose/mannitol(L/M)ratio[(4.56±0.78)U/mL,(5.04±0.46)mg/L,0.24±0.04],hemorheology indexes such as whole blood viscosity(high shear)value,platelet adhesion rate,the ratio of viscosity and hematocrit[(4.96±0.32)map/s,36.73％±3.54％,1.75％±0.14％,40.35％±3.47％],C-reactive protein(CRP),IL-17,and IL-6[(52.62±3.72)mg/L,(6.56±0.57)ng/L,(5.06±0.45)ng/L]in the observation group were lower than those in the control group[(7.04±0.86)U/mL,(6.23±0.57)mg/L,0.51±0.06],[(5.67±0.45)map/s,52.96％±3.62％,1.97％±0.12％,44.24％±3.52％],[(68.34±3.94)mg/L,(8.25±0.78)ng/L,(7.74±0.63)ng/L],and the differences were statistically significant(P<0.05).Conclusion Micro intravenous infusion of octreotide in the treatment of acute pancreatitis can effectively improve intestinal mucosal function,and reduce inflammatory factor expression levels.
octreotideacute pancreatitisadministration methodintestinal mucosal function
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