Effect of sodium tanshinone ⅡA sulfonate combined with aspirin on cardiac function in patients with angina pectoris of coronary heart disease
Objective To investigate the clinical effect of sodium tanshinone ⅡA sulfonate combined with aspirin on pa-tients with angina pectoris of coronary heart disease and its influence on cardiac function.Methods Patients with angina pecto-ris from Beijing Rehabilitation Hospital Affiliated to Capital Medical University from June 2021 to June 2023 were selected and divided into group A and group B by random number table method.Group A was treated with tanshinone ⅡA sulfonate com-bined with aspirin,and group B was treated with aspirin monotherapy.Both groups were treated for 2 weeks.The clinical effi-cacy of the two groups was compared,and the changes in angina pectoris attack,myocardial enzyme level and hemorheology indexes before and after treatment were observed,and safety analysis was conducted.Results A total of 120 patients were in-cluded,60 patients in group A and 60 patients in group B.After 2 weeks of treatment,the total clinical response rate of group A was higher than that of group B,and the frequency,duration,and the levels of creatine kinase,creatine kinase isoenzyme,lactate dehydrogenase,alpha-hydroxybutyrate dehydrogenase,fibrinogen,plasma viscosity and whole blood viscosity of angi-na pectoris were lower than those of group B with statistical significance(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Sodium tanshinone ⅡA sulfonate com-bined with aspirin has a good effect and safety in patients with coronary heart disease and angina pectoris,which can alleviate clinical symptoms,improve cardiac function and hemorheology.
sodium tanshinone ⅡA sulfonateaspirincoronary heart diseaseangor pectoriscardiac function
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