丹参酮ⅡA磺酸钠联合阿司匹林治疗冠心病心绞痛的疗效及其对心功能的影响
Effect of sodium tanshinone ⅡA sulfonate combined with aspirin on cardiac function in patients with angina pectoris of coronary heart disease
马小民 1刘自双 1杜歌 1张新峰 1陈珊珊 1杨凯1
作者信息
- 1. 首都医科大学附属北京康复医院 老年医学科,北京 102300
- 折叠
摘要
目的 探讨丹参酮ⅡA磺酸钠联合阿司匹林治疗冠心病心绞痛患者的临床疗效及其对心功能的影响.方法 选取2021年6月至2023年6月首都医科大学附属北京康复医院就诊的冠心病心绞痛患者,采用随机数字表法将其分为A组和B组,A组采用丹参酮ⅡA磺酸钠联合阿司匹林治疗,B组采用阿司匹林单药治疗,两组均治疗2周.比较两组患者的临床疗效,观察治疗前后心绞痛发作情况、心肌酶水平和血液流变学指标的变化,并进行安全性分析.结果 共纳入120例患者,A组和B组各60例.治疗2周后,A组患者临床治疗总有效率高于B组,心绞痛发作频率、持续时间及肌酸激酶、肌酸酶同工酶、乳酸脱氢酶、α-羟基丁酸脱氢酶、纤维蛋白原、血浆黏度和全血黏度水平均低于B组,差异有统计学意义(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05).结论 丹参酮ⅡA磺酸钠联合阿司匹林对冠心病心绞痛患者有较好的疗效,能缓解临床症状,改善心功能及血液流变学,且安全性良好.
Abstract
Objective To investigate the clinical effect of sodium tanshinone ⅡA sulfonate combined with aspirin on pa-tients with angina pectoris of coronary heart disease and its influence on cardiac function.Methods Patients with angina pecto-ris from Beijing Rehabilitation Hospital Affiliated to Capital Medical University from June 2021 to June 2023 were selected and divided into group A and group B by random number table method.Group A was treated with tanshinone ⅡA sulfonate com-bined with aspirin,and group B was treated with aspirin monotherapy.Both groups were treated for 2 weeks.The clinical effi-cacy of the two groups was compared,and the changes in angina pectoris attack,myocardial enzyme level and hemorheology indexes before and after treatment were observed,and safety analysis was conducted.Results A total of 120 patients were in-cluded,60 patients in group A and 60 patients in group B.After 2 weeks of treatment,the total clinical response rate of group A was higher than that of group B,and the frequency,duration,and the levels of creatine kinase,creatine kinase isoenzyme,lactate dehydrogenase,alpha-hydroxybutyrate dehydrogenase,fibrinogen,plasma viscosity and whole blood viscosity of angi-na pectoris were lower than those of group B with statistical significance(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Sodium tanshinone ⅡA sulfonate com-bined with aspirin has a good effect and safety in patients with coronary heart disease and angina pectoris,which can alleviate clinical symptoms,improve cardiac function and hemorheology.
关键词
丹参酮ⅡA磺酸钠/阿司匹林/冠心病/心绞痛/心功能Key words
sodium tanshinone ⅡA sulfonate/aspirin/coronary heart disease/angor pectoris/cardiac function引用本文复制引用
出版年
2024
NETL
NSTL
万方数据