A survey of application status of macrolides in the treatment of chronic rhinosinusitis
Objective To understand the current status of macrolides used in the treatment of chronic rhinosinusitis(CRS),and to provide a basis for the rationality and safety of macrolides for CRS.Methods A questionnaire survey was conducted among Chinese otolaryngologists to assess attitudes,prescribing habits,and safety concerns about prescribing macrolides to patients with CRS.Results A total of 478 questionnaires were returned,with a validity rate of 100.0％.Most of the respondents believed that they would prescribe macrolides to patients with CRS when necessary,and"Sometimes","often"and"infrequently"prescribed macrolides 38.7％,31.0％,and 20.1％,respectively.Clarithromycin dominated,and was followed by roxithromycin,they were usually given in regular dosage,and about 97.7％of the otolaryngologists opted for a shorter course of treatment(less than 3 months),with a greater tendency to prefer 2 to 4 weeks and 1 to 2 weeks.42.7％,17.8％,45.8％,and 37.4％of the respondents had never undergone blood routine tests,IgE level tests,allergen,and drug sensitivity tests before prescribing macrolides,respectively.41.4％of the respondents had never paid attention to the interactions of macrolides with other drugs;for special populations,1.5％,4.2％,and 47.9％of respondents prescribed macrolides for chronic CRS patients during pregnancy,lactation,and children.Conclusion Most otolaryngologists follow relevant domestic and international guidelines to use macrolides,but there are still gaps in the applicable population,dosage,and course of treatment.At the same time,more attention should be paid to the combination of drugs to reduce the risk of serious adverse events.
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