A retrospective analysis of the effectiveness and safety of amphotericin B in the treatment of acquired immune deficiency syndrome with deep fungal infection
Objective To retrospectively analyze the effectiveness and safety of amphotericin B in AIDS patients with deep fungal infection.Methods A retrospective review was conducted on the medical records of AIDS patients treated with amphotericin B for deep fungal infections at Beijing Ditan Hospital,Capital Medical University,from January 1,2019,to May 31,2023.The effectiveness and safety indicators during the treatment period were monitored and analyzed.Results A total of 25 patients were included.The overall effectiveness rate was 84.0％and the symptom improvement rate was 68.0％;22 cases experienced adverse reactions,and 12 cases experienced serious adverse reactions.The most common types of adverse reac-tions were hypokalemia,bone marrow suppression,renal impairment,and liver function abnormality.Conclusion Amphoter-icin B demonstrates great clinical efficacy in treating deep fungal infections in AIDS patients.However,due to its high rate of adverse reactions,close monitoring is required during clinical use.
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