Research progress on population pharmacokinetics of sirolimus in pediatric diseases
Sirolimus is a macrolide immunosuppressant commonly used to treat pediatric patients with tuberous sclerosis,immune-related diseases,vascular anomalies,and vascular tumors in recent years.However,there are significant interindivid-ual differences in the pharmacokinetic processes of sirolimus within patients,which necessitates regular therapeutic drug moni-toring.The application of population pharmacokinetic(PPK)methods is crucial in guiding and optimizing dosing regimens.Currently,due to the limited scope of domestic and international studies on sirolimus PPK,the existing models are not fully de-veloped.This article provides a comprehensive summary of the progress in sirolimus PPK research,discussing measures for op-timizing sirolimus models.The review aims to facilitate the future establishment of PPK models for sirolimus in various diseases and the development of individualized treatment approaches.
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