A therapeutic drug for myelodysplastic syndrome:pevonedistat
Pevonedistat is a novel inhibitor of neuronal precursor cell-expressed developmentally down-regulated pro-tein 8(NEDD8)activating enzyme.The drug disrupts the protein and causes tumor cell apoptosis by interfering with the biolog-ical activity of the NEDD8 activating enzyme.The therapeutic effect of pevonedistat on myelodysplastic syndrome and related hematological tumor diseases has been validated by multiple clinical studies.This article reviews the basic information,mecha-nism of action,pharmacokinetics,clinical efficacy,and safety of pevonedistat,aiming to provide a reference for clinical appli-cations.
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