基于CHARLS数据库的中国老年人群髋部骨折与用药相关性分析
Analysis of correlation between hip fracture and medication use in the Chinese elderly population based on the CHARLS database
蔺建蕊 1阮佳琦 1王海鸽 1王晓剑 1郭明星 1崔向丽1
作者信息
- 1. 首都医科大学附属北京友谊医院 药剂科,北京 100050
- 折叠
摘要
目的 探讨中国老年人群髋部骨折与用药的关系.方法 提取2018年中国健康与退休纵向研究数据库(CHARLS)60岁及以上并报告药物使用的人群,统计髋部骨折、慢性疾病及药物使用等资料,通过LAS-SO回归分析髋部骨折的相关风险因素,并确定风险因素比值比.结果 共纳入样本人群10 848例,其中髋部骨折人群141例(1.30%).60岁及以上老年人跌倒史(OR=4.86,95%CI:3.41～6.91)、年龄(OR=1.02,95%CI:1.00～1.05)、抗抑郁/镇静催眠药(OR=3.11,95%CI:1.38～7.01)、抗帕金森/阿尔兹海默病药物(OR =2.15,95%CI:1.19～3.87)、镇痛药(OR=1.74,95%CI:1.19～2.55)与髋部骨折相关(P<0.05).结论 跌倒史、年龄、抗抑郁/镇静催眠药、抗帕金森/阿尔兹海默病药物、镇痛药与60岁及以上老年人群髋部骨折明显相关.
Abstract
Objective To investigate the relationship between hip fracture and pharmacotherapy in the Chinese elderly population.Methods Data were extracted from the China Health and Retirement Longitudinal Study(CHARLS)database in 2018,focusing on subjects aged 60 years old and above who reported medication use.Information on hip fractures,chronic diseases,and medication use was collected.The risk factors associated with hip fracture were screened by lasso regression anal-ysis and represented by risk factor ratio.Results A total of 10 848 cases were included in the study,of which 141(1.30%)were hip fracture population.Falls(OR=4.86,95%CI:3.41-6.91),age(OR=1.02,95%CI:1.00-1.05),antidepressant/sed-ative-hypnotics(OR=3.11,95%CI:1.38-7.01),anti-Parkinsonian/Alzheimer's drugs(OR=2.15,95%CI:1.19-3.87),and analgesics(OR=1.74,95%CI:1.19-2.55)were associated with hip fracture,with statistically significant differences in the re-sults(P<0.05).Conclusion Falls,age,anti-Parkinsonian/Alzheimer's drugs,antidepressants/sedative-hypnotics,and anal-gesics were significantly associated with hip fracture in the elderly people aged 60 years old and above.
关键词
髋部骨折/老年人群/药物治疗/中国健康与退休纵向研究数据库Key words
hip fracture/elderly population/pharmacotherapy/China Health and Retirement Longitudinal Study data-base引用本文复制引用
出版年
2024
NETL
NSTL
万方数据