Comparative efficacy of different fat emulsions containing ω-3 polyunsaturated fatty acids in the nutritional support of critically ill patients
Objective To compare the efficacy of fat emulsions containing ω-3 polyunsaturated fatty acids(ω-3 PUFA)in the nutritional support of critically ill patients.Methods A retrospective analysis was conducted on the clinical data of criti-cally ill patients treated with containing ω-3 PUFA-based fat emulsions in Lu'an Hospital Affiliated to Anhui Medical Universi-ty from May 2018 to May 2023.According to the total parenteral nutrition(TPN)prescription of different fat emulsions compo-sition,patients were divided into multi-oil lipid emulsion group and ω-3 fish oil lipid emulsion combined with long or medi-um/long chain lipid emulsion group.The total hospitalization stay,ICU stay duration,total cost of lipid emulsion,total hospi-talization cost,total cost of TPN treatment,proportion of medical costs,hepatoprotective drug usage rate,patient improve-ment rate,total bilirubin,albumin,AST,ALT,WBC count,neutrophils percentage,and C-reactive protein(CRP)levels were compared between the two groups.Results A total of 106 cases were included in the multi-oil lipid emulsion group and 76 cases in the ω-3 fish oil lipid emulsion combined with long or medium/long chain lipid emulsion group.After treatment,there were no significant differences in total hospitalization stay,ICU stay duration,total hospitalization cost,hepatoprotective drug usage rate of and patient improvement rate between the two groups(P>0.05).Compared with the ω-3 fish oil lipid emul-sion combined with long or medium/long chain lipid emulsion group,the multi-oil liupid emulsion group showed significant reductions in total lipid emulsion cost,total TPN treatment cost,and the proportion of medication costs(P<0.05).No signifi-cant differences were observed between the two groups in the improvement of liver function and inflammatory index levels(P>0.05).Conclusion In the design of TPN prescriptions for critically ill patients,using the multi-oil lipid emulsion can replace ω-3 fish oil lipid emulsion combined with long or medium/long chain lipid emulsion to control the proportion of medication costs,with no difference in clinical efficacy between the two prescriptions.
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