信迪利单抗致史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症一例
Stevens-Johnson syndrome and toxic epidermal necrolysis induced by sintilimab treatment:a case report
邓晓兰 1黄仕思 2元建华3
作者信息
- 1. 海口市人民医院 药学部,海口 570208
- 2. 海口市人民医院 医疗保健科,海口 570208
- 3. 海口市人民医院 肿瘤化疗科,海口 570208
- 折叠
摘要
本文对1例非小细胞肺癌青年女性患者首次使用信迪利单抗后接受吉西他滨单药化疗联合局部放疗后出现史蒂文斯-约翰逊综合征(SJS)/中毒性表皮坏死松解症(TEN)进行详细分析.免疫治疗所致SJS/TEN罕见但致死率高,而联合化疗和(或)放疗风险可能增加,需谨慎选择,治疗期间加强不良反应监测,并及时识别与处理至关重要.
Abstract
This study presents a detailed analysis of a case involving a young female patient with non-small cell lung can-cer who developed Stevens-Johnson syndrome(SJS)and toxic epidermal necrolysis(TEN)after receiving her first dose of pem-brolizumab followed by single-agent chemotherapy with gemcitabine and concurrent radiotherapy.SJS/TEN caused by immu-notherapy,though rare,is associated with high mortality,and the risk may be increased with combination chemotherapy and/or radiotherapy.Therefore,caution should be exercised in selecting treatment options,and close monitoring for adverse reac-tions,as well as timely identification and management,are crucial during the treatment period.
关键词
信迪利单抗/吉西他滨/史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症/放疗Key words
sintilimab/gemcitabine/Stevens-Johnson syndrome and toxic epidermal necrolysis/radiation therapy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据