Immune-related adverse reactions caused by tislelizumab:two cases report
In case 1,the patient experienced erythema,herpes,and pustules covering more than 30%of the body area,accompanied by limited self-care ability after using tislelizumab,which was considered as grade 3 cutaneous immune-related adverse events(irAEs).Although cutaneous irAEs are common adverse reactions of tislelizumab,the initial onsite of the pa-tient's skin irAEs was adjacent to the joint on the same side of the tumor,which was easy to ignore.The scope of cutaneous irAEs rapidly expanded to the whole body.No reports in multiple domestic and international databases have mentioned the cor-relation between the occurrence site(para-articular)of skin irAEs and the location of tumor lesions.In case 2,the patient de-veloped hypothyroidism after using tislelizumab,along with a rare significant increase in creatine kinase level and an extremely rare pericardial effusion.Both patients improved after early active treatment.Combined with the literature,this article analyzes the characteristics,treatment methods,immune rechallenge,and prognostic factors related to tislelizumab irAEs,to promote clinical medication safety.
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