Study on the effect of blood pressure control of compound reserpine and triamterene tablets based on real-world data
Objective To analyze the effect of compound reserpine and triamterene tablets on blood pressure control among hypertensive patients in the real world.Methods Conducted a retrospective analysis based on Electronic Medical Records in Qingdao west Coast District from 2012 to 2019.Hypertensive patients who took compound reserpine and amitriptyline tab-lets were selected as the intervention group;and hypertensive patients who did not use the drug but used other antihypertensive medications were matched according to gender,age,and BMI in a 1∶1 ratio and regarded as the control group.General infor-mation,medication,and blood pressure control status of patients were collected.Linear,logistic,and cox regression analyses were comprehensively used to analyze the correlation between taking the drug and blood pressure control at 45 days and the in-cidence of new cardiovascular events.Results A total of 4860 patients were included(2627 in the intervention group and 2233 in the control group).Among them,3335(68.6%)achieved blood pressure targets during the follow-up period,and 360(7.4%)had new cardiovascular events.Multivariate linear and logistic regression analysis showed that taking compound reserpine and amphotericin tablets reduced the systolic blood pressure(P<0.05)and increased blood pressure compliance rate(P<0.01)at the end of the follow-up period.Multivariate Cox regression analysis showed that taking compound reserpine and amitriptyline tablets is an independent protective factor for cardiovascular new events,and the risk of cardiovascular new events can be reduced by 20%(HR=0.80,95%CI:0.65～0.99);regular use of this drug can lower the risk of new cardiovascu-lar events by 34%(HR=0.66,95%CI:0.45～0.97).Conclusion Taking compound reserpine and amphotericin tablets can effectively help control blood pressure and reduce the risk of new cardiovascular events;regular use of compound reserpine and amphotericin tablets shows more significant effects in lowering blood pressure and cardiovascular protection.
real world datacompound reserpine and triamterene tabletshypertension
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