舌下含服粉尘螨滴剂治疗成人变应性鼻炎的短期疗效观察
Short-term efficacy of sublingual dust mite drops in the treatment of allergic rhinitis in adults
韩成成 1方国军 2代键 3张雨3
作者信息
- 1. 蚌埠医科大学研究生院,安徽 蚌埠 233030
- 2. 蚌埠医科大学研究生院,安徽 蚌埠 233030;安徽医科大学附属六安医院 耳鼻咽喉头颈外科,安徽 六安 233000
- 3. 安徽医科大学附属六安医院 耳鼻咽喉头颈外科,安徽 六安 233000
- 折叠
摘要
目的 评估舌下含服粉尘螨滴剂治疗尘螨过敏成人变应性鼻炎的短期疗效.方法 选取2021年11月至2023年1月就诊于安徽医科大学附属六安医院耳鼻咽喉头颈外科舌下含服粉尘螨滴剂治疗满6个月的成人变应性鼻炎患者,分析治疗前后主观、客观检查指标变化.结果 与治疗前比较,治疗后视觉模拟评分法(VAS)评分、鼻炎症状总评分(TNSS)、鼻结膜炎生活质量问卷(RQLQ)评分均有不同程度降低;外周血嗜酸性粒细胞计数及百分比、鼻腔分泌物嗜酸性粒细胞阳性比例降低;血清特异性IgE水平、鼻腔最大吸气流量上升,差异均有统计学意义(P<0.05).结论 舌下含服粉尘螨滴剂治疗尘螨过敏成人变应性鼻炎的短期疗效较好,血清特异性IgE水平、鼻腔分泌物嗜酸性粒细胞阳性比例及鼻腔最大吸气流量可作为变应性鼻炎免疫治疗的疗效评估客观依据.
Abstract
Objective To assess the short-term efficacy of sublingual dust mite drops in treating dust mite allergy-in-duced allergic rhinitis in adults.Methods Adult allergic rhinitis patients treated with sublingual dust mite drops for 6 months at the Department of Otorhinolaryngology and Head and Neck Surgery of Lu'an Hospital,Anhui Medical University from No-vember 2021 to January 2023 were selected.Changes in subjective and objective examination indexes before and after treat-ment were analyzed.Results Compared with the pre-treatment period,the visual analog scale(VAS)score,total nasal con-junctival symptom score(TNSS),and rhinoconjunctivitis quality of life questionnaire(RQLQ)score all significantly decreased post-treatment;peripheral blood eosinophil counts and the percentage,positive proportion of eosinophils in nasal secretions were reduced;while the serum specific IgE levels and peak nasal inspiratory flow increased,all the differences were statistical-ly significant(P<0.05).Conclusion Sublingual dust mite drops show good short-term efficacy in treating dust mite allergy-in-duced allergic rhinitis in adults.Serum-specific IgE levels,percentage of eosinophil in nasal secretions,and peak nasal inspira-tory flow can be used as objective measures for assessing the efficacy of immunotherapy for allergic rhinitis.
关键词
粉尘螨滴剂/变应性鼻炎/尘螨/特异性免疫治疗Key words
dust mite drops/allergic rhinitis/dust mites/specific immunotherapy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据