Analysis of severe thrombocytopenia caused by regorafenib:a case report
This article reported a case of an 85-year-old male patient with atrial fibrillation for over 20 years and liver cancer for 13 years.He had regularly taken rivaroxaban for 3 years with mild thrombocytopenia(platelet count over minimum mean 100×109/L).One month ago,liver magnetic resonance imaging of this patient indicated the progress of liver cancer.Af-ter switching to regorafenib therapy for 22 days,his platelet count decreased to 29×109/L.After consultation with clinical phar-macists,it was considered as severe thrombocytopenia induced by regorafenib,and the possibility of rivaroxaban exacerbating thrombocytopenia cannot be ruled out.Therefore,regorafenib and rivaroxaban were discontinued,and symptomatic treatment was given,the platelet count of the patient gradually increased to 60×109/L,and the patient was discharged in stable condition.
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