A novel drug for the treatment of demodex blepharitis:lotilaner
Lotilaner is a novel isoxazoline compound and a non-competitive antagonist of gamma-aminobutyric acid(GABA)receptors.In July 2023,the U.S.FDA approved lotilaner for the treatment of adult Demodex blepharitis.By inhibit-ing GABA receptors,lotilaner can cause spastic paralysis in Demodex mites,leading to starvation and death.This article aims to review the pharmacology,pharmacokinetics,clinical evaluation,safety,dosage and administration of lotilaner.
lotilanerDemodex blepharitisgamma-aminobutyric acid receptorsclinical study
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