Causal association study of antidepressants and myocardial infarction based on Mendelian randomization method
Objective To investigate the causal relationship between antidepressants and myocardial infarction.Methods A two-sample Mendelian randomization(MR)method was used,utilizing GWAS data from the Finnish database and the MRC Integrative Epidemiology Unit database.Genetic variants related to antidepressants were selected as instrumental variables,and the causal relationship between antidepressants and myocardial infarction was analyzed using the inverse vari-ance weighted method.Sensitivity analyses were conducted to assess the robustness of the results including heterogeneity tests,horizontal pleiotropy tests,and leave-one-out analysis.Results A total of 16 genetic variants associated with antidepressants were selected as instrumental variables.There was a causal relationship between antidepressants and myocardial infarction(OR=1.160,95%CI:1.058 to 1.272,P<0.05).The heterogeneity test results indicated no heterogeneity in the causal rela-tionship between antidepressants and myocardial infarction(P>0.05).The horizontal pleiotropy test results showed no hori-zontal pleiotropic effects of the genetic proxies for antidepressants on myocardial infarction(P>0.05).Conclusion Antidepres-sants may increase the risk of myocardial infarction in patients,and clinical use should be closely monitored.
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