Safety evaluation of minocycline and doxycycline in paediatric patients based on FDA adverse event reporting system database
Objective To mine the risk signals of minocycline and doxycycline in paediatric patients and provide refer-ence for safe drug use.Methods The FDA adverse event reporting system database was queried using the OpenVigil 2.1 plat-form to obtain the adverse drug events(ADEs)of minocycline and doxycycline from the first quarter of 2004 to the first quarter of 2023,with an age limit of 0-17 years.Reporting odds ratios(ROR)was used to detect the risk signals.Results A total of 2965 ADE reports related to minocycline and 1431 ADE reports related to doxycycline were extracted,respectively.The most common reported ADEs of minocycline was abdominal discomfort,with the strongest signal being arterial thrombosis.The most common reported ADEs of doxycycline was Jarisch-Herxheimer reaction,with the strongest signal being neutrophilic der-matosis.Conclusion Routine monitoring of gastrointestinal,liver damage,and skin-related ADEs is recommended when us-ing minocycline and doxycycline,and new ADEs should also be concerned.
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