Hepatitis B virus reactivation caused by long-term administration of rituximab in a patient with waldenstr?m macroglobulinemia:a case report
This article reports a 96-year-old male patient with Waldenström macroglobulinemia and positive HBsAb only.The patient,who was on a regular intravenous rituximab regimen,showed serological reversal of HBsAg,HBV-DNA positivity,and abnormal liver function during follow-up.After comprehensive screen,physician judged it as the reactivation of hepatitis B virus caused by rituximab.Rituximab was discontinued,and the patient was treated with oral entecavir for antiviral therapy and wuzhi capsules for hepatoprotection and enzyme reduction.The patient's condition was stable and serious adverse events were avoided.The analysis of this case aims to provide a reference for rational use of rituximab.
rituximabhepatitis B virushepatitis B virus surface antibodyWaldenström macroglobulinemiahepatitis B virus reactivation
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