Daratumumab in the treatment of proliferative glomerulonephritis with monoclonal immunoglobulin deposition:a case report
This article presents report a rare case of proliferative glomerulonephritis with monoclonal immunoglobulin de-position.The patient was a 49-year-old female,the clinical manifestations were nephrotic syndrome,Renal biopsy pathology indicated proliferative glomerulonephritis with monoclonal immunoglobulin(IgG3-κ)deposition.Dexamethasone+cyclo-phosphamide+thalidomide(CTDa)regimen provided complete remission at the initial treatment,but bortezomib+dexameth-asone(BD)regimen was ineffective after recurrence,and renal function abnormalities occurred.After daratumumab therapy,the disease gradually remission and renal function returned to normal.
proliferative glomerulonephritis with monoclonal immunoglobulin depositionclonal directed therapybort-ezomibdaratumumab
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