Acute cerebral infarction and coronary thrombosis induced by avatrombopag:a case report
The article reported a case of a 43-year-old male who was treated with avatrombopag due to primary immune thrombocytopenia,resulting in acute cerebral infarction and coronary thrombosis.Before treatments,the platelet count(PLT)was 30×109/L.5 days later,the patient had acute cerebral infarction with the PLT 107×109/L.Since the PLT count decreased to 30×109/L afterwards,he was treated with avatrombopag again.5 days later,the patient had a chest pain,with the PLT count elevating to 206×109/L.Coronary angiography and optical coherence tomography suggested the presence of a thrombus in the mid-segment of the right coronary artery.The acute coronary syndrome was considered to be related to elevation of platelets caused by avatrombopag.After consultation with a clinical pharmacist and hematologist,the physicians were advised to stop avatrombopag,and start aspirin and clopidogrel for antiplatelet therapy.The antiplatelet medication was adjusted based on the PLT levels.During the follow-up,the patient did not experience any thrombosis events.
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