The association between opioid drugs and gallstones based on two-sample bidirectional Mendelian randomization and the FDA adverse event reporting system database
Objective To analyze the association between opioid drugs and gallstones,provide reference for the rational use of opioid drugs in gallstone patients.Methods Two-sample bidirectional Mendelian randomization(MR)analysis was used to predict the association between opioid drugs and gallstones at the genetic level,validated it using real-world adverse drug reaction data recorded in the FDA adverse event reporting system(FAERS)database.Results Genetic prediction showed that the use of opioid drugs was associated with gallstones.The inverse variance weighted results of forward MR analysis were OR=1.12,95%CI:1.02 to 1.24,P<0.05,β=0.114,and there was no inverse association interference in the results.FAERS database confirms that opioid drugs are associated with gallstones,but not all opioid drugs are associated with gallstones.Complete agonists of μ receptors are associated with gallstones,while partial agonists of μ receptors and mixed agonists antagonists of opioid receptors have no risk of gallstones.Conclusion The risk of gallstones with opioid drugs may be related to pharmacological mechanisms of action.Patients with gallstones should use μ1 receptor high selective agonists,μ receptor partial agonists,and opioid receptor mixed agonists antagonists and avoid the use of low selective varieties of μ receptor complete agonists.
NETL
NSTL
万方数据
